Emmanuelle Schindler

Role of Neuroendocrinological Systems in the Effects of Psychedelics

Several biological and psychological mechanisms have been investigated in the consideration of the therapeutic effects of psychedelics, particularly their unique ability to produce lasting changes after limited dosing. The known actions of the drug class on neuroendocrine systems warrant continued exploration, as there are also neuroendocrinological aberrations in the medical conditions shown to benefit from psychedelic therapy. Dr. Schindler will discuss the relevant neuroanatomy, hormonal functions, and circadian rhythms involved, with a particular focus on cluster headache, a debilitating headache disorder reported to benefit from treatment with psychedelics and related compounds. Methodological considerations for future investigations will also be discussed, as such factors as timing and pattern of drug administration may influence therapeutic outcomes.

Dr. Schindler is a board-certified Neurologist at Yale School of Medicine in New Haven, Connecticut. She completed neurology residency and fellowship training at Yale and has expertise in headache medicine. Among her efforts to optimise the management of headache disorders, she has ongoing clinical trials seeking to understand the effects and mechanisms of action of psilocybin in cluster, migraine, and post-traumatic headache. Previously, she studied the neuropharmacology of psychedelics and other serotonergic compounds in the context of receptor binding and intracellular signalling at Drexel University College of Medicine, where she received her Ph.D. (2010) and M.D. (2012). She also graduated summa cum laude from the College of William & Mary where she received a B.S. in Biological Psychology in 2003. Dr. Schindler has won several awards for academic excellence, has a number of publications and invited book chapters, and remains at the forefront of headache medicine.